S. Saha

Translation-independent association of mRNAs encoding protomers of the 5-HT2A-mGlu2 receptor complex in living cells

The paper shows that mRNAs for 5-HT2A and mGlu2 receptors associate co-translationally without requiring their encoded proteins, using in vitro and ex vivo experiments.

Diminished Immune Cell Adhesion in Hypoimmune ICAM-1 Knockout Pluripotent Stem Cells

This paper identifies ICAM-1 as a novel hypoimmune target in human pluripotent stem cells, showing that its knock-out reduces immune cell adhesion and enhances graft survival.

Legionella uses host Rab GTPases and BAP31 to create a unique ER niche

This study shows Legionella pneumophila transforms the host ER membrane into a distinct rER niche using Rab GTPases and BAP31.

The SET1 protein of Leishmania donovani moderates the parasite's response to a hostile oxidative environment

This study investigates the role of LdSET1 in Leishmania donovani, finding it moderates the parasite's response to oxidative stress in host macrophages, enabling infection persistence without host cell eradication.

Maramycin, a cytotoxic isoquinolinequinone terpenoid produced through heterologous expression of a bifunctional indole prenyltransferase /tryptophan indole-lyase in S. albidoflavus

The paper reports the discovery of maramycin, a novel isoquinolinequinone alkaloid produced through heterologous expression of a bifunctional enzyme in Streptomyces albidoflavus, showing moderate cytotoxicity against prostate cancer cells.

Molecular basis of ligand promiscuity, structural mimicry, and atypical dimerization in the chemokine receptors

This study investigates ligand promiscuity and signaling bias in chemokine receptors by analyzing binding modes and determining cryo-EM structures of receptor-ligand complexes.

Methyl substituted β-lactam framework based antibiotics and β-lactamase inhibitors: Proof of concept by computations

This paper presents a computational proof of concept for methyl-substituted β-lactam antibiotics that slow deacylation of the acyl-enzyme complex by 109-fold without affecting binding to β-lactamase.

LGR5+ Intestinal Stem Cells Display Sex Dependent Radiosensitivity

This study shows male LGR5+ intestinal stem cells are more radiosensitive than female ones, with differences not linked to sex hormones.

The Effects of Preeclamptic Milieu on Cord Blood Derived Endothelial Colony-Forming Cells

This study examines how the preeclamptic environment affects cord blood-derived endothelial colony-forming cells, finding impaired function and potential for improvement with treatment.

Enhancing Drug Delivery with Supramolecular Amphiphilic Macrocycle Nanoparticles: Selective Targeting of CDK4/6 Inhibitor Palbociclib to Melanoma

This paper develops amphiphilic macrocycle nanoparticles for targeted drug delivery of Palbociclib to melanoma cells, showing selective targeting and minimal toxicity.

Mass lysis of bacterial predators drives the enrichment of antibiotic resistance in soil microbial communities

The paper shows that introducing Myxococcus xanthus in soil increases antibiotic resistance by lysing cells, creating a toxic environment that favors resistant bacteria.

A comprehensive analysis of Transcribed Ultra Conserved Regions uncovers important regulatory functions of novel non-coding transcripts in gliomas.

This study analyzes Transcribed Ultra Conserved Regions (TUCRs) in gliomas, identifying uc.110 as a tumor enhancer that promotes malignancy via the WNT pathway.

Metallo-protease Peptidase M84 from Bacillus altitudinis induces ROS dependent apoptosis in ovarian cancer cells by targeting PAR-1

This paper identifies Peptidase M84 from Bacillus altitudinis as an apoptosis inducer in ovarian cancer cells via PAR-1 mediated oxidative stress, showing anti-tumor effects in vitro and in vivo.

Putative staphylococcal enterotoxin possesses two common structural motifs for MHC-II binding

This study characterizes a putative staphylococcal enterotoxin, SEl26, showing its structural similarity to conventional SAgs and its ability to bind MHC-II and modulate cytokines.

Structure of the human Duffy antigen receptor

This study determines the cryo-EM structure of the Duffy antigen receptor bound to CCL7, revealing structural features that explain its unique functional properties and lack of G protein coupling.

Molecular insights into atypical modes of beta-arrestin interaction with seven transmembrane receptors

This study presents cryo-EM structures and experimental data revealing how beta-arrestins interact with GPCRs, particularly those with phosphorylation in the third intracellular loop and intrinsically biased receptors.

Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution

This study presents cryo-EM structures of GPR109A-G-protein complexes with agonists and uses them to engineer biased agonists with reduced flushing effects.

Regulation of apico-basolateral trafficking polarity of homologous Copper-ATPases ATP7A and ATP7B

This study identifies AP-1 isoforms as regulators of apico-basolateral trafficking polarity of ATP7A and ATP7B in polarized epithelia.

Gardnerella vaginolysin potentiates glycan molecular mimicry by Neisseria gonorrhoeae

This study shows that Gardnerella vaginolysin releases host cell contents that enhance Neisseria gonorrhoeae's ability to mimic host glycans and evade immune detection.

More than just an Eagle Killer: The freshwater cyanobacterium Aetokthonos hydrillicola produces highly toxic dolastatin derivatives

This paper identifies and characterizes new toxic dolastatin derivatives produced by the freshwater cyanobacterium Aetokthonos hydrillicola, revealing its potential threat to ecosystems and human health.

Functional connectivity in northern swamp deer (Rucervus duvaucelii duvaucelii) population across a fragmented, human-dominated landscape along Gangetic Plains of north India: Implications for conservation in non-protected areas

The paper assesses genetic connectivity and dispersal patterns of northern swamp deer in a human-dominated landscape, finding two genetic lineages with low inbreeding and identifying conservation priorities.

Mixing selects for predation resistance in lab-evolved communities of bacterial prey and social predator Myxococcus xanthus

This study shows that repeated mixing in predator-prey communities increases prey resistance to predation but does not affect predator efficiency.

Structural insights into agonist-binding and activation of the human complement C3a receptor

This study presents structural insights into C3a-C3aR interactions and identifies a G-protein-biased agonist for the receptor.

Toxic metal uptake by oyster mushrooms grown in sugarcane bagasse

This study investigates metal uptake by oyster mushrooms grown on sugarcane bagasse, finding biomagnification of heavy metals in mushrooms compared to the substrate.

Anthelmintic efficacy of Holarrhena pubescens against Raillietina spp. of domestic fowl through ultrastructural, histochemical, biochemical and GLCM analysis

This paper evaluates the anthelmintic effects of Holarrhena pubescens extracts on Raillietina spp. using ultrastructural, histochemical, biochemical, and GLCM analysis, finding the ethyl acetate fraction most effective.

Signaling in microbial communities with open boundaries

This study uses mathematical modeling to show how boundary flows and population geometry affect cell-cell signaling in microbial communities with open boundaries, revealing new insights into signaling mechanisms and making experimentally verifiable predictions.

Structural insights into ligand-recognition, activation, and signaling-bias at the complement C5a receptor, C5aR1

This study presents cryo-EM structures of C5aR1 bound to C5a and a synthetic peptide, revealing conformational changes and G-protein coupling mechanisms.

Kinesin family motors modify transcription mediated by ERR1 using a conserved nuclear receptor box motif

This study shows that KIF1B, a kinesin-3 motor, uses an LxxLL motif to inhibit ERR1-dependent transcription by regulating ERR1 nuclear entry, distinct from KIF17's mechanism.

Structural snapshots uncover a lock-and-key type conserved activation mechanism of β-arrestins by GPCRs

The paper presents structural snapshots of β-arrestins interacting with GPCRs, revealing a conserved 'lock-and-key' activation mechanism through specific phosphorylation patterns.

Hepatitis C virus non-structural proteins modulate cellular kinases for increased cytoplasmic abundance of host factor HuR and facilitate viral replication

This study identifies how HCV proteins NS3 and NS5A modulate host kinases to increase cytoplasmic HuR levels, enhancing viral replication.