The C-terminal activating domain promotes Panx1 channel opening
E. Henze, J. Ehrlich, J. L. Robertson, T. Kawate
This paper identifies the C-terminal activating domain (CAD) as essential for Panx1 channel opening, showing how its cleavage repositions the N-terminus to reduce anion accumulation and promote ion permeability.
bioRxiv · Jun 13, 2024 · PreprintBiophysics