Author

T. Kawate

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 4 Organism:bacteria (other)· 2 Assay:proteomics· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

D. T. Hung· 3 shared A. Golas· 2 shared E. O. Johnson· 2 shared E. Office· 2 shared M. Fitzgerald· 2 shared T. Warrier· 2 shared A. Boeszoermenyi· 1 shared B. B. Aldridge· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersMicrobiology

D. T. Hung

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Massively parallel combination screen reveals small molecule sensitization of antibiotic-resistant Gram-negative ESKAPE pathogens

M. W. Tse, M. Zhu, B. Peters, E. Hamami, J. Chen, K. P. Davis, S. Nitz, J. Weller, T. Warrier, D. K. Hunt, Y. Morales, T. Kawate, J. L. Gaulin, J. H. Come, J. Hernandez-Bird, , P. C. Blainey

This study uses high-throughput screening to identify small molecules that enhance antibiotic efficacy against multidrug-resistant Gram-negative bacteria.

bioRxiv · Mar 26, 2024 · PreprintMicrobiology

Multiplexed screen identifies a Pseudomonas aeruginosa-specific small molecule targeting the outer membrane protein OprH and its interaction with LPS

T. Warrier, B. E. Poulsen, S. Barkho, J. Bagnall, K. P. Romano, T. White, X. Yu, T. Kawate, P. H. Nguyen, K. Raines, K. Ferrara, A. Golas, M. Fitzgerald, A. Boeszoermenyi, V. Kaushik, , D. T. Hung

The paper identifies a Pseudomonas aeruginosa-specific small molecule, BRD1401, that targets OprH and disrupts its interaction with LPS, increasing membrane fluidity.

bioRxiv · Mar 16, 2024 · PreprintMicrobiology

ATP-release pannexin channels are gated by lysophospholipids

E. Henze, R. N. Burkhardt, B. W. Fox, T. J. Schwertfeger, E. Gelsleichter, K. Michalski, L. Kramer, M. Lenfest, J. M. Boesch, H. Lin, F. C. Schroeder, T. Kawate

The paper identifies lysophospholipids as activators of pannexin channels, showing they trigger ATP and other metabolite release, and activate inflammasomes in human monocytes.

bioRxiv · Oct 23, 2023Biophysics

A large-scale chemical-genetic strategy to design antimicrobial combination chemotherapy for Mycobacterium tuberculosis

E. O. Johnson, E. Office, T. Kawate, M. Orzechowski, D. T. Hung

This paper identifies two synergistic EfpA inhibitors for tuberculosis that exhibit collateral sensitivity, demonstrating a strategy for designing antimicrobial combinations using chemical-genetic interactions.

bioRxiv · Sep 27, 2019 · PreprintMicrobiology

Large-scale chemical-genetics yields new Mycobacterium tuberculosis inhibitor classes

E. O. Johnson, E. LaVerriere, M. Stanley, E. Office, E. Meyer, T. Kawate, J. Gomez, R. E. Audette, N. Bandyopadhyay, N. Betancourt, K. Delano, I. Da Silva, J. Davis, C. Gallo, M. Gardner, , Schnappinge

This study uses a novel chemical-genetics screening strategy to identify new inhibitors of Mycobacterium tuberculosis, revealing novel compound classes targeting previously unexplored bacterial targets.

bioRxiv · Jan 16, 2019Microbiology