The IPF fibroblastic focus is an active collagen biosynthesis factory embedded in a distinct extracellular matrix
J. A. Herrera, L. Dingle, M. A. Montero, R. Shah, R. V. Venkateswaran, J. F. Blaikley, C. Lawless, M. A. Schwartz
The paper uses spatial proteomics to show that the IPF fibroblastic focus is a major site of collagen biosynthesis with distinct ECM composition compared to surrounding tissues.
bioRxiv · Nov 6, 2021Pathology