M. A. Schwartz

Gamma protocadherins in vascular endothelial cells inhibit Klf2/4 to promote atherosclerosis

This study identifies Pcdhg as a suppressor of Klf2/4 in endothelial cells, promoting atherosclerosis by inhibiting the Notch pathway.

Focal adhesion-derived liquid-liquid phase separations regulate mRNA translation

This study shows that p130Cas-dependent liquid-liquid phase separation from focal adhesions inhibits mRNA translation, linking high adhesion to reduced translation in myofibroblasts and senescent cells.

cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling

The paper uses cSTAR to analyze endothelial cell transcriptomic states under different flow conditions, identifies CDK2 as a key regulator of artery remodeling.

Mechanosensing through talin 1 contributes to tissue mechanical homeostasis

This study shows that mutations in talin1 alter cellular stiffness sensing, leading to changes in ECM mechanical properties and aortic compliance.

A novel cancer-associated cassette exon in TLN1 alters Talin 1 mechanosensitivity

The paper identifies a cancer-associated exon in TLN1 that alters mechanosensitivity by affecting R1-R2 switch dynamics and vinculin binding.

Calcium flux through ER-TGN contact sites facilitates cargo export

The paper shows that Ca2+ flux through ER-TGN contact sites is essential for cargo export via SPCA1 and Cab45, using a FRET sensor to measure real-time Ca2+ flow.

ESCRT-dependent STING degradation curtails steady-state and cGAMP-induced signaling

The paper identifies an ESCRT complex that degrades STING to suppress its signaling, showing its role in maintaining immune homeostasis.

Fibronectin-integrin α5 signaling promotes thoracic aortic aneurysm in a mouse model of Marfan syndrome

This study shows that fibronectin-integrin α5 signaling drives thoracic aortic aneurysms in Marfan syndrome mice, with a 5/2 chimera mutation reducing aneurysm severity.

The IPF fibroblastic focus is an active collagen biosynthesis factory embedded in a distinct extracellular matrix

The paper uses spatial proteomics to show that the IPF fibroblastic focus is a major site of collagen biosynthesis with distinct ECM composition compared to surrounding tissues.

MEKK3-TGFβ crosstalk regulates inward arterial remodeling

This study identifies endothelial MEKK3 as a regulator of inward arterial remodeling through TGFβ-Smad2/3 signaling, leading to hypertension and atherosclerosis.

Defective flow-migration coupling causes arteriovenous malformations in hereditary hemorrhagic telangiectasia

This study shows that defective flow-migration coupling due to ALK1 loss causes arteriovenous malformations in HHT, with integrin-YAP/TAZ signaling as a potential therapeutic target.

Fibronectin-mediated inflammatory signaling through integrin α5 in vascular remodeling

This study shows that replacing integrin α5 with a chimeric α5/α2 integrin reduces vascular remodeling and inflammation in mouse models.

Laser capture microdissection coupled mass spectrometry (LCM-MS) for spatially resolved analysis of formalin-fixed and stained human lung tissues

This paper develops an optimized microproteomics method for analyzing H&E-stained FFPE lung tissues, identifying 1252 differentially expressed proteins including 137 ECM proteins.

Fibronectin receptor integrin α5β1 regulates assembly of PP2A complexes through PDE4D: modulation of vascular inflammation and atherosclerosis

This study shows that integrin α5β1 regulates PP2A complex assembly via PDE4D5, reducing vascular inflammation and atherosclerosis in mice.