Cell BiologybioRxiv
Obesity-linked PPARγ S273 phosphorylation promotes insulin resistance through Growth Differentiation Factor 3
J. A. Hall, D. Ramachandran, H. C. Roh…·A. Banks
This study shows that preventing PPARγ S273 phosphorylation reduces insulin resistance without weight gain or side effects, identifying Gdf3 as a key mediator.
DOI 10.1016/j.cmet.2020.08.016