Author

B. Spiegelman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

D. Tenen· 2 shared A. Banks· 1 shared A. Charpagne· 1 shared A. I. Mina· 1 shared A. Lyubetskaya· 1 shared A. Parisi· 1 shared B. B. Kahn· 1 shared B. Dawes· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

D. Tenen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

REPTOR/CREBRF encode key regulators of muscle energy metabolism

P. Saavedra, P. A. Dumesic, Y. Hu, P. Jouandin, R. Binari, S. Wilensky, E. Filine, J. Rodiger, H. Wang, B. Spiegelman, N. Perrimon

This study identifies REPTOR/CREBRF as key regulators of muscle energy metabolism, showing they repress glycolysis and promote oxidative phosphorylation in both flies and mammals.

bioRxiv · Dec 17, 2021Physiology

Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo

E. G. Estell, P. T. Le, Y. Vegting, H. Kim, R. Baron, B. Spiegelman, C. J. Rosen

This study shows irisin directly promotes osteoclast differentiation and bone resorption in vitro and in vivo, suggesting it regulates bone remodeling beyond its effects on osteoblasts.

bioRxiv · May 9, 2020Cell Biology

Obesity-linked PPARγ S273 phosphorylation promotes insulin resistance through Growth Differentiation Factor 3

J. A. Hall, D. Ramachandran, H. C. Roh, J. R. DiSpirito, T. Belchior de Oliveira, P.-J. H. Zushin, C. J. Palmer, S. Hong, A. I. Mina, B. Liu, Z. Deng, P. Aryal, C. Jacobs, D. Tenen, C. W. Brown, , A. Banks

This study shows that preventing PPARγ S273 phosphorylation reduces insulin resistance without weight gain or side effects, identifying Gdf3 as a key mediator.

bioRxiv · Jan 13, 2020Cell Biology

PGC1a and Exercise Adaptations in Zebrafish

A. Parisi, P. Blattmann, G. Lizzo, V. Stutz, L. Strohm, J. Richard, G. Civiletto, A. Charpagne, F. Raymond, C. Gobet, B. Weger, E. Migliavacca, R. Aebersold, B. Spiegelman, P. Gut

This study shows that PGC1a induces mitochondrial biogenesis and exercise-like adaptations in zebrafish, revealing conserved exercise responses and novel ETC organization.

bioRxiv · Dec 7, 2018 · PreprintPhysiology

Thermoneutrality induces skeletal muscle myopathy via brown adipose tissue in an IRF4- and myostatin-dependent manner

X. Kong, P. Zhou, T. Yao, L. Kazak, D. Tenen, A. Lyubetskaya, B. Dawes, L. Tsai, B. Kahn, B. Spiegelman, T. Liu, E. D. Rosen

This study shows that thermoneutrality causes skeletal muscle myopathy through brown adipose tissue via IRF4 and myostatin mechanisms.

bioRxiv · Mar 2, 2018Physiology