Obesity-linked PPARγ S273 phosphorylation promotes insulin resistance through Growth Differentiation Factor 3
J. A. Hall, D. Ramachandran, H. C. Roh, J. R. DiSpirito, T. Belchior de Oliveira, P.-J. H. Zushin, C. J. Palmer, S. Hong, A. I. Mina, B. Liu, Z. Deng, P. Aryal, C. Jacobs, D. Tenen, C. W. Brown, , A. Banks
This study shows that preventing PPARγ S273 phosphorylation reduces insulin resistance without weight gain or side effects, identifying Gdf3 as a key mediator.
bioRxiv · Jan 13, 2020Cell Biology