Author

D. Ramachandran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Evolutionary Biology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. S. Banks· 4 shared A. A. Adhikari· 2 shared A. S. Devlin· 2 shared M. D. McCurry· 2 shared S. N. Chaudhari· 2 shared A. Banks· 1 shared A. Gulko· 1 shared A. I. Mina· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersCell Biology

A. S. Banks

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

GDF3 is an obesity-induced regulator of TGFβ superfamily signaling

D. Ramachandran, N. Kotikalapudi, G. R. Gipson, L. Troncone, K. Vestal, D. E. Maridas, A. Gulko, L. T. Tsai, V. Rosen, P. B. Yu, T. B. Thompson, A. S. Banks

This study identifies GDF3 as an obesity-induced regulator that modulates TGFβ superfamily signaling by inhibiting BMP and activating activin-like SMAD 2/3 pathways in adipose tissue.

bioRxiv · Nov 7, 2022 · PreprintCell Biology

A gut-restricted lithocholic acid analog as an inhibitor of gut bacterial bile salt hydrolases

A. A. Adhikari, D. Ramachandran, S. N. Chaudhari, C. E. Powell, M. D. McCurry, A. S. Banks, A. S. Devlin

The paper develops a gut-restricted BSH inhibitor, AAA-10, which effectively reduces secondary bile acids in mice with minimal systemic exposure.

bioRxiv · Mar 15, 2021Biochemistry

Evolutionary dynamics of transposable elements following a shared polyploidization event in the tribe Andropogoneae

D. Ramachandran, M. R. McKain, E. A. Kellogg, J. S. Hawkins

The paper examines TE activity and accumulation in polyploid species of the Andropogoneae tribe, finding variation in repeat content and expansion of copia elements in species adapted to temperate environments.

bioRxiv · Mar 5, 2020Evolutionary Biology

Obesity-linked PPARγ S273 phosphorylation promotes insulin resistance through Growth Differentiation Factor 3

J. A. Hall, D. Ramachandran, H. C. Roh, J. R. DiSpirito, T. Belchior de Oliveira, P.-J. H. Zushin, C. J. Palmer, S. Hong, A. I. Mina, B. Liu, Z. Deng, P. Aryal, C. Jacobs, D. Tenen, C. W. Brown, , A. Banks

This study shows that preventing PPARγ S273 phosphorylation reduces insulin resistance without weight gain or side effects, identifying Gdf3 as a key mediator.

bioRxiv · Jan 13, 2020Cell Biology

A big-data approach to understanding metabolic rate and response to obesity in laboratory mice

J. K. Corrigan, D. Ramachandran, Y. He, C. Palmer, M. J. Jurczak, B. Li, R. H. Friedline, J. K. Kim, J. J. Ramsey, L. Lantier, O. P. McGuinness, A. S. Banks, Mouse Metabolic Phenotyping Center Energy Balance Working Group

This study analyzes indirect calorimetry data from thousands of mice to identify sources of metabolic variation and provides guidelines for designing and reporting metabolic experiments.

bioRxiv · Nov 12, 2019Physiology

Development of a Covalent Inhibitor of Gut Bacterial Bile Salt Hydrolases

A. A. Adhikari, T. C. Seegar, S. B. Ficarro, M. D. McCurry, D. Ramachandran, L. Yao, S. N. Chaudhari, S. Ndousse-Fetter, A. S. Banks, J. A. Marto, S. C. Blacklow, A. S. Devlin

This study develops a covalent inhibitor of gut bacterial bile salt hydrolases, showing it reduces BSH activity and deconjugated bile acids in mice.

bioRxiv · May 17, 2019Microbiology