ImmunologybioRxiv
Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation
I. V. Hochheiser, H. Behrmann, G. Hagelueken…·M. Geyer
The paper determines the directionality of PYD filament growth by showing ASC elongates exclusively on the B-end of NLRP3 filaments, enabling a transition from NLRP3 nucleation to ASC elongation.