Author

I. V. Hochheiser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

E. Latz· 2 shared G. Hagelueken· 2 shared M. Geyer· 2 shared A. Kopp· 1 shared C. Engel· 1 shared E. Behrmann· 1 shared H. Behrmann· 1 shared J. F. Rodriguez-Alcazar· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

E. Latz

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Author profile →

2 papers

Recent·Most cited

Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation

I. V. Hochheiser, H. Behrmann, G. Hagelueken, J. F. Rodriguez-Alcazar, A. Kopp, E. Latz, E. Behrmann, M. Geyer

The paper determines the directionality of PYD filament growth by showing ASC elongates exclusively on the B-end of NLRP3 filaments, enabling a transition from NLRP3 nucleation to ASC elongation.

bioRxiv · Nov 25, 2021Immunology

Cryo-EM structure of the NLRP3 decamer bound to the cytokine release inhibitory drug CRID3

I. V. Hochheiser, M. Pilsl, G. Hagelueken, J. Moecking, M. Marleaux, R. Brinkschulte, E. Latz, C. Engel, M. Geyer

The paper determines the cryo-EM structure of NLRP3 bound to CRID3, revealing how the inhibitor stabilizes the protein and provides insights for drug development.

bioRxiv · Jul 22, 2021Immunology