Structure of a dominant negative mutant reveals a stalled intermediate in anthrax protective antigen pore maturation
H. Scott, W. Huang, S. Ganti, K. Zhang, N. Mehzabeen, A. Day, K. P. Battaile, S. Lovell, J. G. Bann, D. J. Taylor
The paper identifies a dominant negative mutation that stalls anthrax protective antigen pore maturation at an intermediate state, revealing structural features and a regulatory mechanism for pore formation.
Journal of Molecular Biology · May 1, 2022Peer-reviewedBiophysics