Author

J. G. Lock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

A. Tong· 1 shared A. Venkat· 1 shared B. Perez San Juan· 1 shared C. Chaffer· 1 shared C. Liu· 1 shared D. Bhaskar· 1 shared D. Mercatelli· 1 shared D. Ziegler· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Tong

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2 papers

Recent·Most cited

Revealing dynamic temporal trajectories and underlying regulatory networks with Cflows

X. Sun, S. Gupta, A. Tong, M. Kuchroo, D. Bhaskar, C. Liu, A. Venkat, B. Perez San Juan, L. Rangel, V. Rodriguez, J. G. Lock, C. Chaffer, S. Krishnaswamy

Cflows infers continuous cell state transitions and gene regulatory networks from static scRNA-seq data, revealing ESRRA as a key driver of tumor formation.

bioRxiv · Mar 28, 2023 · PreprintCancer Biology

Copper chelation inhibits TGF-β pathways and suppresses epithelial-mesenchymal transition in cancer

E. M. Poursani, D. Mercatelli, P. Raninga, J. L. Bell, F. Saletta, F. V. Kohane, Y. Zheng, J. Rouaen, T. R. Jue, F. T. Michniewicz, E. Kasiou, M. Tsoli, G. Cirillo, S. Waters, T. Shai-Hee, , O. VITTORIO

This paper shows copper chelation inhibits TGF-β pathways and reduces EMT in cancer cells, potentially offering a new therapeutic strategy for targeting TGF-β in cancer.

bioRxiv · Oct 3, 2022 · PreprintCancer Biology