A. Venkat

Redox Regulation of Brain Selective Kinases BRSK1/2: Implications for Dynamic Control of the Eukaryotic AMPK family through Cys-based mechanisms

This study investigates how redox regulation via cysteine oxidation controls BRSK1/2 kinase activity, revealing conserved mechanisms that modulate catalytic function through disulfide bond formation and salt bridge disruption.

Mechanistic and evolutionary insights into isoform-specific 'supercharging' in DCLK family kinases

This study investigates how isoform-specific variations in DCLK family kinases affect autoregulation through structural and functional analyses.

Revealing dynamic temporal trajectories and underlying regulatory networks with Cflows

Cflows infers continuous cell state transitions and gene regulatory networks from static scRNA-seq data, revealing ESRRA as a key driver of tumor formation.

Evolution of functional diversity in the holozoan tyrosine kinome

This study classifies holozoan tyrosine kinases using sequence constraints, identifies new subgroups, and links functional diversity to evolutionary changes in kinase domains.

KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases

KinOrtho maps human kinase orthologs across 17,000 species, identifies understudied kinases, and proposes their functions using domain-based approaches and machine learning.

A reservoir of stem-like CD8 T cells in the tumor-draining lymph node maintains the ongoing anti-tumor immune response

The paper identifies a reservoir of stem-like CD8 T cells in tumor-draining lymph nodes that sustain anti-tumor immunity by maintaining TCF1 expression and resisting terminal differentiation.

Multinucleotide mutations cause false inferences of lineage-specific positive selection

The paper shows that multinucleotide mutations can falsely indicate positive selection in phylogenetic tests, suggesting many published findings may be artifacts.