Anticodon Edited Transfer RNAs (ACE-tRNAs) Encoded as Therapeutic Nonviral Minimal DNA Vectors
Joseph J. Porter, Wooree Ko, Emily G. Sorensen, Zachary Cheung, Kari Thrasher, Tyler A. Couch, J. Gabell, Victoria Shwe, Julia Hyatt, Jennasea B. Licata, Luke K Peterson, David Allen Dean, John D. Lueck
This paper demonstrates that DNA-based ACE-tRNA minivectors effectively suppress nonsense mutations in CFTR and REP1, with improved bioavailability and stability compared to plasmid DNA vectors.
Nucleic Acids Research · Jan 23, 2026Peer-reviewedMolecular Biology