Tyler A. Couch

Anticodon Edited Transfer RNAs (ACE-tRNAs) Encoded as Therapeutic Nonviral Minimal DNA Vectors

This paper demonstrates that DNA-based ACE-tRNA minivectors effectively suppress nonsense mutations in CFTR and REP1, with improved bioavailability and stability compared to plasmid DNA vectors.

The impact of subunit type, alternative splicing, and auxiliary proteins on AMPA receptor trafficking

This study assesses the impact of AMPA receptor subunit type, alternative splicing, and auxiliary proteins on trafficking using high-throughput methods, finding subunit type as the most significant factor.

Unique Pharmacology of mGluR homo- and heterodimers

This study examines the pharmacological properties of mGlu receptor homodimers and heterodimers, finding unique signaling responses to ligands that challenge generalizable rules of dimeric interactions.

Proline substitutions in the ASIC1 β11-12 linker slow desensitization

This study shows that proline substitutions in the ASIC1 β11-12 linker significantly slow desensitization, with minimal effects on activation and ion selectivity.

Anticodon Engineered Transfer RNAs (ACE-tRNAs) are a Platform Technology for Suppressing Nonsense Mutations

The paper demonstrates that ACE-tRNAs can suppress nonsense mutations in CF by rescuing CFTR transcript abundance and channel function in multiple models.