C. Lenz

Profiling the LAM family of contact site tethers provides insights into their regulation and function

The paper profiles the LAM family of contact site tethers to understand their localization and function, revealing unique and shared roles through proximity labeling.

Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14Delta/+ mice hearts

Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity

The paper optimizes a 2-aminopyrimidine-based macrocycle to create a dual EPHA2/GAK kinase inhibitor with antiviral activity against dengue virus.

Uncovering the temporal dynamics and regulatory networks of thermal stress response in a hyperthermophile using transcriptomics and proteomics

This study uses transcriptomics and proteomics to analyze the thermal stress response in Pyrococcus furiosus, revealing rapid transcriptome reprogramming and persistent protein upregulation during heat shock.

Dystrophin is a mechanical tension modulator

This study shows that dystrophin modulates baseline homeostatic tension in skeletal muscle, linking increased tissue tension to DMD pathogenesis.

Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair

This study identifies DPP9 as a regulator of BRCA2 stability and DNA-damage repair by promoting its degradation via the N-degron pathway.

SugarQuant: a streamlined pipeline for multiplexed quantitative site-specific N-glycoproteomics

SugarQuant provides a pipeline for site-specific N-glycoproteomics, enabling confident quantification of glycoforms in complex samples.