Author

R. Zhubi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. C. Joerger· 2 shared A. Kraemer· 2 shared L. Elson· 2 shared L. M. Berger· 2 shared S. Knapp· 2 shared T. Hanke· 2 shared A. Lucic· 1 shared A. Poso· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersBiochemistry

A. C. Joerger

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2 papers

Recent·Most cited

Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity

J. Gerninghaus, R. Zhubi, A. Kraemer, M. Karim, D. H. N. Tran, A. C. Joerger, C. Schreiber, L. M. Berger, B. T. Berger, T. A. L. Ehret, L. Elson, C. Lenz, K. Saxena, S. Mueller, S. Einav, , T. Hanke

The paper optimizes a 2-aminopyrimidine-based macrocycle to create a dual EPHA2/GAK kinase inhibitor with antiviral activity against dengue virus.

bioRxiv · Feb 18, 2024 · PreprintBiochemistry

Shifting the selectivity of pyridopyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily

M. Rak, R. Tesch, L. M. Berger, E. Shevchenko, M. Raab, A. Tjaden, R. Zhubi, D.-I. Balourdas, A. C. Joerger, A. Poso, A. Kraemer, L. Elson, A. Lucic, T. Kronenberger, T. Hanke, , S. Knapp

This paper develops a selective SIK kinase inhibitor, MR22, by optimizing a pyrido[2,3-d]pyrimidin-7(8H)-one scaffold to eliminate PAK activity, demonstrating its efficacy in ovarian cancer cells.

European Journal of Medicinal Chemistry · Jun 1, 2023Peer-reviewedBiochemistry