J. Gertsch

A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor-selective full agonist for in vivo studies

This paper develops and characterizes RNB-61, a potent and selective CB2R agonist with favorable pharmacokinetics, showing nephroprotective effects in kidney injury models.

Silicon-rhodamine functionalized evocalcet probes (EvoSiR) potently and selectively label calcium sensing receptors (CaSR) in vitro, in vivo and ex vivo

This paper develops fluorescent probes EvoSiR4 and EvoSiR6 that potently and specifically label CaSR in vitro, in vivo, and ex vivo, outperforming evocalcet and its linker conjugate.

Phylobioactive hotspots identified through multidimensional profiling of botanical drugs used to treat Chagas disease in Bolivia and Dioscorides' De Materia Medica

This study compares botanical drugs used for Chagas disease in Bolivia with those from Dioscorides' De Materia Medica to identify phylobioactive hotspots and assess their antitrypanosomal activity.