Author

U. Grether

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Le Gouill· 2 shared C. Ullmer· 2 shared J. Fingerle· 2 shared M. Bouvier· 2 shared T. Miljus· 2 shared W. Guba· 2 shared A. C. Rufer· 1 shared A. Caruso· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

C. Le Gouill

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor-selective full agonist for in vivo studies

A. Chicca, D. Batora, C. Ullmer, A. Caruso, J. Fingerle, T. Hartung, R. Degen, M. Mueller, U. Grether, P. Pacher, J. Gertsch

This paper develops and characterizes RNB-61, a potent and selective CB2R agonist with favorable pharmacokinetics, showing nephroprotective effects in kidney injury models.

bioRxiv · Apr 26, 2024 · PreprintPharmacology & Toxicology

Multiple triggers converge to preferential effector coupling in the CB2R through a complex allosteric communication network

A. Morales-Pastor, T. Miljus, T. M. Stepniewski, V. Ledesma, F. Heydenreich, T. Flock, B. Plouffe, C. Le Gouill, J. Duchaine, W. Guba, A. Rufer, U. Grether, M. Bouvier, D. Veprintsev, J. Selent

The paper investigates how multiple triggers on an allosteric communication network influence preferential coupling of the CB2R to Gi2 over β-arrestin1, revealing insights into GPCR signaling mechanisms.

bioRxiv · Feb 27, 2024 · PreprintCell Biology

Diverse chemotypes drive biased signaling by cannabinoid receptors

T. Miljus, F. M. Heydenreich, T. Gazzi, A. Kimbara, M. Rogers-Evans, M. Nettekoven, E. Zirwes, A. Osterwald, A. C. Rufer, C. Ullmer, W. Guba, C. Le Gouill, J. Fingerle, M. Nazare, U. Grether, , D. B. Veprintsev

This study identifies chemotype-specific biased signaling in cannabinoid receptors by analyzing ligand-induced signaling cascades.

bioRxiv · Nov 9, 2020 · PreprintPharmacology & Toxicology