The YARS Tyrosyl tRNA Synthetase Regulates Senescence Induction and Escape Through the Transcriptional Control of LIN9, a Member of the DREAM Complex
H. Coquelet, G. Leman, A. Maarouf, C. Petit, B. Toutain, C. Henry, A. Boissard, C. Guette, E. Lelievre, P. Vidi, J. Guillon, O. Coqueret
This study identifies YARS as a transcriptional regulator that promotes senescence escape by enhancing LIN9 expression through epigenetic modifications.
bioRxiv · Dec 19, 2023 · PreprintCancer Biology