C. Henry

Airway smooth muscle tone curbs hyperresponsiveness in experimental asthma

This study investigates how airway smooth muscle tone affects methacholine response in mice with and without experimental asthma, finding it mitigates hyperresponsiveness during inflammation.

The ANKS3/BICC1 protein complex is a master post-transcriptional regulator of NPHP1 ciliopathy gene transcripts

The paper identifies ANKS3/BICC1 as a post-transcriptional regulator of NPHP1 transcripts, linking it to ciliopathy phenotypes through transcript decay and ciliary dysfunction.

A widespread family of ribosomal peptide metallophores involved in bacterial adaptation to copper stress

This paper identifies bufferins, a widespread family of ribosomal peptide metallophores that help bacteria adapt to copper stress by sequestering excess copper ions.

Mapping the soil microbiome functions shaping wetland methane emissions

The paper maps soil microbiome functions in wetlands to understand methane emissions by analyzing microbial communities and gene expression across spatial and temporal gradients.

The YARS Tyrosyl tRNA Synthetase Regulates Senescence Induction and Escape Through the Transcriptional Control of LIN9, a Member of the DREAM Complex

This study identifies YARS as a transcriptional regulator that promotes senescence escape by enhancing LIN9 expression through epigenetic modifications.

Spatiotemporal dynamics of single-stranded DNA intermediates in Escherichia coli

The paper uses fluorescence microscopy to study the spatiotemporal dynamics of single-stranded DNA in live E. coli cells, revealing patterns associated with DNA repair and replication.

Development of SARS-CoV-2 mRNA vaccines encoding spike N-terminal and receptor binding domains

The paper develops and evaluates an mRNA vaccine, mRNA-1283, encoding SARS-CoV-2 spike N-terminal and receptor-binding domains, showing improved immunogenicity and protection against multiple variants in mice.

Oxidative Stress is Intrinsic to Staphylococcal Adaptation to Fatty Acid Synthesis Antibiotics

This study shows that anti-FASII antibiotics induce oxidative stress in S. aureus, which enhances adaptation by improving eFA incorporation and survival.

Periplasmic oxidized-protein repair during copper stress in E. coli: a focus on the metallochaperone CusF.

This study shows that copper stress in E. coli activates the CusSR system to induce MsrPQ, which repairs oxidized methionine residues in CusF, maintaining copper efflux pump function.

tRNA Biogenesis and Specific Aminoacyl-tRNA Synthetases Regulate Senescence Stability Under the Control of mTOR

This study identifies specific tRNAs and their ligases that regulate senescence stability through mTOR and RNA polymerase III pathways.

HypVW is an HOCl-Sensing Two Component System in Escherichia coli

This study identifies HypVW as an HOCl-sensing two-component system in E. coli that regulates the expression of the MsrPQ repair system.

Variant SARS-CoV-2 mRNA vaccines confer broad neutralization as primary or booster series in mice

This study evaluates updated SARS-CoV-2 mRNA vaccines in mice, showing that mRNA-1273.351 boosts neutralization against B.1.351 and mRNA-1273.211 provides broad cross-variant protection.

An egg-derived sulfated N-Acetyllactosamine glycan is an antigenic decoy of influenza virus vaccines

This study identifies an egg-derived sulfated N-Acetyllactosamine glycan in influenza vaccines that acts as an antigenic decoy, inducing antibodies that may reduce immune response to protective epitopes.

Critical Assessment of Metaproteome Investigation (CAMPI): a Multi-Lab Comparison of Established Workflows

CAMPI evaluates metaproteomic workflows across labs, finding sample processing drives peptide variability while workflows yield similar functional profiles.

A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin

This study identifies a class of broadly neutralizing antibodies targeting a conserved membrane-proximal epitope on influenza HA, showing their induction by a chimeric HA vaccine.

mRNA-1273 efficacy in a severe COVID-19 model: attenuated activation of pulmonary immune cells after challenge

This study evaluates mRNA-1273 vaccine efficacy in hamsters, showing reduced pulmonary immune activation and improved disease outcomes after prime-boost vaccination.

A novel drug-combination screen in zebrafish identifies epigenetic small molecule candidates for Duchenne muscular dystrophy

The paper identifies two epigenetic small molecules, oxamflatin and salermide, that improve skeletal muscle structure in zebrafish models of Duchenne muscular dystrophy through a drug-combination screen.

Alteration of cardiolipin-dependent mitochondrial coupling in muscle protects against obesity

This study identifies Hacd1 as a regulator of mitochondrial membrane composition in muscle, showing that reduced mitochondrial coupling protects against obesity.

Identification of antibodies targeting the H3N2 hemagglutinin receptor binding site following vaccination of humans

This study identifies H3N2 HA RBS-targeting antibodies in humans, showing some can be broadly reactive despite sensitivity to substitutions near the RBS.

Permissive Fatty Acid Incorporation in Host Environments Promotes Staphylococcal Adaptation to FASII Antibiotics

This study shows that Staphylococcus aureus can adapt to FASII antibiotics by incorporating environmental fatty acids in host conditions, challenging the assumption of fatty acid stringency.

Microbial and Metabolic Succession on Common Building Materials Under High Humidity Conditions

This study investigates microbial and metabolic succession on building materials under high humidity, finding that wetting and material type significantly influence microbial communities and metabolite profiles.

Hemagglutinin stalk-reactive antibodies interfere with influenza virus neuraminidase activity by steric hindrance

This study shows HA-stalk-reactive antibodies inhibit neuraminidase activity via steric hindrance, blocking viral egress and enhancing protection against influenza.