Author

J. Hofvander

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

K. B. Jones· 2 shared M. Hirst· 2 shared T. M. Underhill· 2 shared T. Nielsen· 2 shared A. Banito· 1 shared A. Carles· 1 shared A. Goytain· 1 shared A. Qiu· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

K. B. Jones

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2 papers

Recent·Most cited

Cell-of-origin epigenome underlies SS18::SSX-mediated transformation

L. A. Hill, R. W. Scott, L. A. Martin, M. Arostegui, G. Davenport, M. Vemon, J. Hofvander, X. Q. Wang, J. Li, T. Nielsen, K. B. Jones, M. Hirst, T. M. Underhill

This study identifies the cell-of-origin of synovial sarcoma as a rare fibroblastic population and shows that SS18::SSX induces an embryonic-like mesenchymal stem cell phenotype.

bioRxiv · May 15, 2024Cancer Biology

Synovial Sarcoma Chromatin Dynamics Reveal a Continuum in SS18:SSX Reprograming

J. Hofvander, A. Qiu, K. Lee, M. Bilenky, A. Carles, Q. Cao, M. Moksa, J. Steif, E. Su, A. Sotiriou, A. Goytain, L. Hill, S. Singer, I. Andulis, J. Wunder, , M. Hirst

This study examines the epigenomic states of synovial sarcoma using multi-omics analysis, revealing a continuum of epigenomic states and identifying H3K4me3 inhibition as a potential therapeutic strategy.

bioRxiv · May 14, 2024 · PreprintCancer Biology