Author

A. Carles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 3 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Assay:proteomics· 1

Frequent Co-Authors

M. Hirst· 3 shared M. Moksa· 3 shared M. Bilenky· 2 shared A. Banito· 1 shared A. Goytain· 1 shared A. Martinez de Paz· 1 shared A. Qiu· 1 shared A. Sotiriou· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCancer Biology

M. Hirst

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Author profile →

3 papers

Recent·Most cited

Synovial Sarcoma Chromatin Dynamics Reveal a Continuum in SS18:SSX Reprograming

J. Hofvander, A. Qiu, K. Lee, M. Bilenky, A. Carles, Q. Cao, M. Moksa, J. Steif, E. Su, A. Sotiriou, A. Goytain, L. Hill, S. Singer, I. Andulis, J. Wunder, , M. Hirst

This study examines the epigenomic states of synovial sarcoma using multi-omics analysis, revealing a continuum of epigenomic states and identifying H3K4me3 inhibition as a potential therapeutic strategy.

bioRxiv · May 14, 2024 · PreprintCancer Biology

The pathognomonic FOXL2 C134W mutation alters DNA binding specificity

A. Carles, G. Trigo-Gonzalez, R. Cao, S.- W. G. Cheng, M. Moksa, M. Bilenky, G. B. Morin, D. G. Huntsman, M. Hirst

This study investigates the molecular effects of the FOXL2 C134W mutation in AGCT by analyzing DNA binding and transcriptome changes in engineered cell lines.

bioRxiv · Mar 20, 2020Cancer Biology

MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2

A. Martinez de Paz, L. Khajavi, H. Martin, R. Claveria-Gimeno, S. tom Dieck, M. S. Cheema, J. V. Sanchez-Mut, M. Moksa, A. Carles, N. Brodie, T. I. Sheikh, M. Freeman, E. Petrotchenko, C. Borchers, E. Schuman, , J. Ausio

This study compares MeCP2-E1 and E2 isoforms, showing differences in DNA binding, protein interactions, and dynamic behavior, with implications for their functional roles in chromatin regulation.

bioRxiv · Aug 17, 2018Biochemistry