Author

A. Sotiriou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 3 Organism:human· 3 Approach:statistical model· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

A. Banito· 3 shared K. B. Jones· 2 shared T. M. Underhill· 2 shared A. C. Faber· 1 shared A. Carles· 1 shared A. Goytain· 1 shared A. Jose· 1 shared A. M. Stamatouli· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCancer Biology

A. Banito

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Author profile →

3 papers

Recent·Most cited

Synovial Sarcoma Chromatin Dynamics Reveal a Continuum in SS18:SSX Reprograming

J. Hofvander, A. Qiu, K. Lee, M. Bilenky, A. Carles, Q. Cao, M. Moksa, J. Steif, E. Su, A. Sotiriou, A. Goytain, L. Hill, S. Singer, I. Andulis, J. Wunder, , M. Hirst

This study examines the epigenomic states of synovial sarcoma using multi-omics analysis, revealing a continuum of epigenomic states and identifying H3K4me3 inhibition as a potential therapeutic strategy.

bioRxiv · May 14, 2024 · PreprintCancer Biology

Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma

K. V. Floros, C. K. Fairchild, J. Li, K. Zhang, J. L. Roberts, R. Kurupi, B. Hu, V. Kraskauskiene, N. Hosseini, S. Shen, M. M. Inge, K. Smith-Fry, L. Li, A. Sotiriou, K. M. Dalton, , A. C. Faber

This study shows that inhibiting SUMOylation with TAK-981 stabilizes cBAF complexes and disrupts the SS18::SSX-driven transcriptome in synovial sarcoma, leading to tumor inhibition.

bioRxiv · Apr 25, 2024 · PreprintCancer Biology

An autoregulatory feedback loop converging on H2A ubiquitination drives synovial sarcoma

N. S. Benabdallah, V. Dalal, A. Sotiriou, R. W. Scott, F. K. Kommoss, A. Pejkovska, L. Gaspar, L. Wagner, F. J. Sanchez-Rivera, M. Ta, S. Thornton, T. O. Nielsen, T. M. Underhill, A. Banito

This study identifies an autoregulatory feedback loop involving H2A ubiquitination that enhances SS18-SSX fusion protein chromatin binding and oncogenic activity in synovial sarcoma.

bioRxiv · Jul 18, 2022 · PreprintCancer Biology