J. I. Martin-Subero

This study characterizes the gene regulatory network of early human B-cell development and identifies regulatory elements linked to B-cell acute lymphoblastic leukemia.

The paper creates a comprehensive cell atlas of the human tonsil using single-cell multi-omics data, identifying 121 cell types and uncovering regulatory mechanisms and disease-related changes.

This study shows NOTCH1 mutations in B cell malignancies promote immune escape by upregulating PD-L1 and silencing HLA-class II, leading to poor clinical outcomes.

This study analyzes DNA methylation in B-cell tumors to show its relation to proliferative history and clinical outcomes, introducing a new mitotic clock for prognosis.

The paper identifies aberrant chromatin activation as a common mechanism driving the malignant phenotype in multiple myeloma.