Evolutionary BiologybioRxiv
Idiosyncratic epistasis leads to global fitness-correlated trends
C. W. Bakerlee, A. N. Nguyen Ba, Y. Shulgina…·M. M. Desai
The paper constructs all combinations of 10 missense mutations in budding yeast and shows that global fitness trends arise from specific idiosyncratic epistatic interactions.
DOI 10.1126/science.abm4774