Author

C. W. Bakerlee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:yeast· 4 Research Focus:development & morphogenesis· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. N. Nguyen Ba· 4 shared M. M. Desai· 4 shared A. M. Phillips· 3 shared A. Moulana· 1 shared A. Rego-Costa· 1 shared E. R. Jerison· 1 shared J. C. Piper· 1 shared J. Goyal· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersEvolutionary Biology

A. N. Nguyen Ba

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4 papers

Recent·Most cited

Idiosyncratic epistasis leads to global fitness-correlated trends

C. W. Bakerlee, A. N. Nguyen Ba, Y. Shulgina, J. I. Rojas-Echenique, M. M. Desai

The paper constructs all combinations of 10 missense mutations in budding yeast and shows that global fitness trends arise from specific idiosyncratic epistatic interactions.

bioRxiv · Sep 22, 2021Evolutionary Biology

Dynamics and variability in the pleiotropic effects of adaptation in laboratory budding yeast populations

C. W. Bakerlee, A. M. Phillips, A. N. Nguyen Ba, M. M. Desai

The paper studies how pleiotropic effects of adaptation in yeast change over time and vary across environments, finding increasing variability and overlapping contributions of chance and contingency.

bioRxiv · Jun 24, 2021Evolutionary Biology

The Genetic Basis of Differential Autodiploidization in Evolving Yeast Populations

S. Tung, C. W. Bakerlee, A. M. Phillips, A. N. Nguyen Ba, M. M. Desai

This study identifies SSD1 gene variants as the genetic determinant of differential autodiploidization rates in yeast strains.

bioRxiv · Mar 10, 2021Evolutionary Biology

Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations

M. S. Johnson, S. Gopalakrishnan, J. Goyal, M. E. Dillingham, C. W. Bakerlee, P. T. Humphrey, T. Jagdish, E. R. Jerison, K. Kosheleva, K. R. Lawrence, J. Min, A. Moulana, A. M. Phillips, J. C. Piper, R. Purkanti, , M. M. Desai

This study tracks phenotypic and molecular evolution in 205 yeast populations over 10,000 generations, revealing patterns of declining adaptability, mutation accumulation, and genetic parallelism.

bioRxiv · Oct 9, 2020Evolutionary Biology