A. N. Nguyen Ba

This study uses scRNA-seq to refine genotype-phenotype mapping in yeast, revealing new associations between transcriptomic and phenotypic variation and highlighting the role of trans-regulation.

The paper constructs all combinations of 10 missense mutations in budding yeast and shows that global fitness trends arise from specific idiosyncratic epistatic interactions.

The paper studies how pleiotropic effects of adaptation in yeast change over time and vary across environments, finding increasing variability and overlapping contributions of chance and contingency.

This study identifies SSD1 gene variants as the genetic determinant of differential autodiploidization rates in yeast strains.

This study tracks phenotypic and molecular evolution in 205 yeast populations over 10,000 generations, revealing patterns of declining adaptability, mutation accumulation, and genetic parallelism.

The paper evolves yeast populations in different environments and finds that pleiotropic effects of mutations are shaped by both deterministic factors and stochastic mutation accumulation.

This study uses experimental evolution of bacteriophage T4 in different host environments to show that structural genes are key determinants of niche breadth evolution.