Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Humans and Mice
N. Ehrhardt, J. Cui, S. Dagdeviren, S. Saengnipanthkul, H. S. Goodridge, J. K. Kim, L. Lantier, X. Guo, Y.-D. I. Chen, L. J. Raffel, T. A. Buchanan, W. A. Hsueh, J. I. Rotter, M. O. Goodarzi, M. Peterfy
This study shows aging impairs insulin sensitivity independently of adiposity in mice and humans, suggesting distinct mechanisms from obesity-related insulin resistance.
bioRxiv · May 30, 2018Physiology