J. K. Kim

Central and peripheral clocks synergistically enhance circadian robustness, flexibility and performance of cardiac pacemaking

This paper develops a mathematical model to study how central and peripheral circadian clocks interact to regulate cardiac pacemaking in adult and aged mice, revealing their synergistic roles in maintaining circadian flexibility and performance.

Partial in vivo reprogramming enables injury-free intestinal regeneration via autonomous Ptgs1 induction

This study shows that partial in vivo reprogramming using OSKM factors induces intestinal regeneration via Ptgs1-driven prostaglandin synthesis, distinct from normal Ptgs2-dependent regeneration.

A new immunocompetent rectal cancer model to study radiation therapy

This paper introduces a mouse model of rectal cancer that mimics human tumor progression and radiation response for preclinical studies.

CRISPR-enhanced human adipocyte 'browning' as cell therapy for metabolic disease

This paper uses CRISPR to enhance browning of human adipocytes, improving metabolic health in mice without immunogenic Cas9 exposure.

Characterization of Viral Insulins Reveals White Adipose Tissue Specific Effects in Mice

This study characterizes double-chain viral insulin-like peptides (dcVILPs) and shows they stimulate glucose uptake in white adipose tissue in mice with higher efficacy than insulin.

A big-data approach to understanding metabolic rate and response to obesity in laboratory mice

This study analyzes indirect calorimetry data from thousands of mice to identify sources of metabolic variation and provides guidelines for designing and reporting metabolic experiments.

Ribosome dimerization prevents loss of essential ribosomal proteins during quiescence

This study shows that HPF in Bacillus subtilis prevents loss of essential ribosomal proteins during quiescence by mediating ribosome dimerization.

RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia

This study shows RNA nucleates phase separation of glycolysis enzymes into G bodies in yeast under hypoxia, revealing their biophysical properties and structural integrity.

Physicochemical Properties of Chromosomes in Live Cells Characterized by Label-Free Imaging and Fluorescence Correlation Spectroscopy

The paper quantifies physicochemical properties of mitotic chromosomes in live cells using label-free imaging and fluorescence correlation spectroscopy, showing correlations between refractive index, volume, and protein mobility under osmotic changes.

Resistance to Diet Induced Obesity in the Apolipoprotein E Deficient Mouse is Associated with an Attenuated Transcriptional Response in Visceral Fat

This study shows that apoE-deficient mice have a reduced transcriptional response in visceral fat to high-fat diet, linked to increased metabolic efficiency and resistance to obesity.

CRISPR delivery particles for developing therapeutic strategies in metabolic disease

This study develops CRISPR delivery particles (CriPs) for efficient gene editing in cultured cells and in vivo, demonstrating their potential for therapeutic applications in metabolic disease.

Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Humans and Mice

This study shows aging impairs insulin sensitivity independently of adiposity in mice and humans, suggesting distinct mechanisms from obesity-related insulin resistance.