Author

Y.-D. I. Chen

The Lundquist Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

X. Guo· 2 shared A. Wood· 1 shared Adithya BalasubramanianiD· 1 shared Adolfo CorreaiD· 1 shared Ali Reza KeramatiiD· 1 shared Allison E. Ashley‐KochiD· 1 shared Álvaro AlonsoiD· 1 shared Amber L. BeitelsheesiD· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersPhysiology

X. Guo

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Author profile →

3 papers

Recent·Most cited

Lac-Phe mediates the anti-obesity effect of metformin

S. Xiao, V. L. Li, X. Lyu, X. Chen, W. Wei, F. Abbasi, J. Knowles, S. Deng, G. Tiwari, X. Shi, S. Deng, L. Farrell, Z.-Z. Chen, K. Taylor, X. Guo, , J. Z. Long

This study identifies Lac-Phe as a mediator of metformin's anti-obesity effects through experiments in mice and human cohorts.

bioRxiv · Nov 2, 2023 · PreprintPhysiology

Genome Sequencing Unveils a New Regulatory Landscape of Platelet Reactivity

Ali Reza Keramati, Ming‐Huei Chen, Benjamin A.T. Rodriguez, Lisa R. Yanek, Arunoday Bhan, Brady J. Gaynor, Kathleen A. Ryan, Jennifer A. Brody, Xue Yun Zhong, Qiang Wei, Namiko Abe, Gonçalo R. Abecasis, François Aguet, Christine M. Albert, Laura A. Almasy, , Paul S. de Vries

The paper uses whole genome sequencing to identify genetic loci associated with platelet aggregation, including novel variants in RGS18, SVEP1, and PEAR1.

Nature Communications · Jun 15, 2021Peer-reviewedGenomics

Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Humans and Mice

N. Ehrhardt, J. Cui, S. Dagdeviren, S. Saengnipanthkul, H. S. Goodridge, J. K. Kim, L. Lantier, X. Guo, Y.-D. I. Chen, L. J. Raffel, T. A. Buchanan, W. A. Hsueh, J. I. Rotter, M. O. Goodarzi, M. Peterfy

This study shows aging impairs insulin sensitivity independently of adiposity in mice and humans, suggesting distinct mechanisms from obesity-related insulin resistance.

bioRxiv · May 30, 2018Physiology