Segregational drift and the interplay between plasmid copy number and evolvability
J. Ilhan, A. Kupczok, C. Woehle, T. Wein, N. F. Huelter, P. Rosenstiel, G. Landan, I. Mizrahi, T. Dagan
This study shows that segregational drift in multicopy plasmids reduces their evolvability by increasing mutation loss and fixation time, despite higher mutational supply.
bioRxiv · Oct 21, 2018Microbiology