P. Rosenstiel

A crypt-operating DNA repair checkpoint for uncoupling regeneration and tumorigenesis

This study identifies Nlrp6 as a regulator of DNA repair and epithelial regeneration in intestinal crypts, linking DNA damage responses to colorectal cancer progression.

Hexokinase 2 expression in apical enterocytes correlates with inflammation severity in patients with inflammatory bowel disease

The paper examines the relationship between HK2 expression and inflammation severity in IBD patients using bulk transcriptome data and confirms findings at the cellular and protein levels.

Intestinal epithelial Atg16l1 influences pregnancy-induced fecal microbiota shifts in mice

This study examines how Atg16l1 deletion in intestinal epithelial cells affects fecal microbiota shifts during pregnancy in mice, identifying altered microbial composition and functional potential.

ATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

This study shows ATF6 activation in colonic epithelial cells alters lipid metabolism, promoting tumor-associated microbial adaptation in mice and human colorectal cancer patients.

Tryptophan wasting and disease activity as a systems phenomenon in inflammation - an analysis across 13 chronic inflammatory diseases.

This study examines tryptophan wasting across 13 chronic inflammatory diseases, finding reduced serum tryptophan levels and increased kynurenine pathway activity linked to disease activity.

Evolution of E. coli in a mouse model of inflammatory bowel disease leads to a disease-specific bacterial genotype and trade-offs with clinical relevance

This study shows that E. coli evolves specific genetic and phenotypic traits in an inflamed gut, leading to antibiotic collateral sensitivity and potential therapeutic implications.

Amino acid auxotrophies in human gut bacteria are linked to higher microbiome diversity and long-term stability

This study links amino acid auxotrophies in human gut bacteria to increased microbiome diversity and long-term stability through a combined metabolomic, metagenomic, and metabolic modeling approach.

Recurrent phases of strict protein limitation inhibit tumor growth and restore lifespan in a Drosophila intestinal cancer model

The paper shows that cyclic severe protein restriction in Drosophila reduces tumor growth, restores gut function, and extends lifespan without the harmful effects of continuous restriction.

Metabolic plasticity of serine metabolism is crucial for cGAS/STING-signalling and innate immune response to viral infections in the gut

The paper identifies metabolic changes in serine metabolism linked to cGAS/STING-signalling and immune response in gut inflammation.

Impact of antibiotic perturbation on intestinal viral communities in mice

The paper examines how antibiotic treatment affects the gut virome in mice, finding delayed resilience and correlations between virome and bacteriome shifts.

Hyperinflammation evokes different antiviral TMPRSS2 and ADAM17 expression responses in human gut xenograft versus host mouse gut although overall genomic responses are similar

This study compares antiviral gene expression responses in human gut xenografts and host mouse gut during hyperinflammation, finding similar genomic responses but species-specific upregulation of TMPRSS2 and ADAM17 in human gut.

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis

This study shows that microbial regulation of HK2 links mitochondrial metabolism and cell death in colitis, with butyrate protecting against inflammation by repressing HK2.

Peripheral sgp130-mediated trans-signaling blockade induces obesity and insulin resistance in mice via PPARα suppression

This study shows that blocking peripheral sgp130-mediated trans-signaling in mice causes obesity and insulin resistance by suppressing PPARα.

Hotspot Dosages of Most Rapid Antibiotic Resistance Evolution

This study investigates how antibiotic resistance evolves in E. coli under varying erythromycin dosages, finding that resistance increases most rapidly just below the minimal inhibitory concentration.

A high-fat diet induces a microbiota-dependent increase in stem cell activity in the Drosophila intestine

This paper shows that a high-fat diet increases intestinal stem cell activity in Drosophila, dependent on microbiota and JNK signaling in enterocytes.

A symbiont phage protein aids in eukaryote immune evasion

The paper identifies a phage-encoded ankyrin domain protein that modulates eukaryotic immune responses, enabling immune evasion in host-microbe interactions.

Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms

The inducible response of the nematode Caenorhabditis elegans to members of its natural microbiome across development and adult life

This study investigates how C. elegans responds to its native microbiome across development and adult life, identifying key molecular processes and regulatory mechanisms.

Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen Pseudomonas aeruginosa

This study tests the evolutionary stability of collateral sensitivity in Pseudomonas aeruginosa, finding that resistance to one antibiotic often leads to hypersensitivity to another, but evolutionary outcomes depend on drug order.

Segregational drift and the interplay between plasmid copy number and evolvability

This study shows that segregational drift in multicopy plasmids reduces their evolvability by increasing mutation loss and fixation time, despite higher mutational supply.