Author

J. J. Hu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Assay:cryo-EM· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Lahiri· 1 shared B. A. Adler· 1 shared E. G. Armbruster· 1 shared H. Wu· 1 shared I. Aphasizheva· 1 shared J. A. Doudna· 1 shared J. K. J. Lee· 1 shared J. Kim· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBiochemistry

A. Lahiri

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Author profile →

3 papers

Recent·Most cited

Hachiman is a genome integrity sensor

O. T. Tuck, B. A. Adler, E. G. Armbruster, A. Lahiri, J. J. Hu, J. Zhou, J. Pogliano, J. A. Doudna

This study identifies Hachiman as a bacterial antiphage defense system that degrades all DNA in response to DNA damage, revealing its role as a genome integrity sensor.

bioRxiv · Feb 29, 2024 · PreprintBiochemistry

CryoEM Reveals Oligomeric Isomers of a Multienzyme Complex and Assembly Mechanics

J. K. J. Lee, Y. Liu, J. J. Hu, I. Aphasizheva, R. Aphasizhev, Z. H. Zhou

This study uses cryoEM to reveal the oligomeric isomers and assembly mechanics of PCC from Leishmania tarentolae, showing how subunit attachment affects enzymatic activity.

bioRxiv · Nov 18, 2022Biophysics

Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D

J. J. Hu, X. Liu, J. Zhao, S. Xia, J. Ruan, X. Luo, J. Kim, J. Lieberman, H. Wu

This paper identifies disulfiram and Bay 11-7082 as pyroptosis inhibitors that covalently modify a conserved cysteine in gasdermin D, thereby blocking pore formation and inflammation.

bioRxiv · Jul 10, 2018Immunology