J. Pogliano

An essential and highly selective protein import pathway encoded by nucleus-forming phage

This paper identifies components of a novel protein import pathway in phages, revealing a mechanism for selective protein trafficking into the phage nucleus.

Hachiman is a genome integrity sensor

This study identifies Hachiman as a bacterial antiphage defense system that degrades all DNA in response to DNA damage, revealing its role as a genome integrity sensor.

Architecture and infection-sensing mechanism of the bacterial PARIS defense system

This study reveals the molecular architecture and infection-sensing mechanism of the bacterial PARIS defense system, showing how it is triggered by a phage counterdefense protein.

A mobile intron facilitates interference competition between co-infecting viruses

The paper shows a mobile intron in bacteriophage ΦPA3 uses its homing endonuclease to interfere with co-infecting phage ΦKZ, providing a competitive reproductive advantage.

A phage nucleus-associated RNA-binding protein is required for jumbo phage infection

This study identifies ChmC, a phage protein that binds RNA and facilitates mRNA transport through the phage nucleus-like compartment, essential for infection.

A transcriptionally active lipid vesicle encloses theinjected Chimalliviridae genome in early infection

The paper shows that Chimalliviridae form a lipid membrane-bound EPI vesicle during early infection, which hosts transcription of the phage genome, and demonstrates the necessity of a second compartment, the phage nucleus, for genome replication.

Identification of the bacteriophage nucleus protein interaction network

The paper identifies proteins interacting with the phage nucleus protein ChmA and describes their potential roles in genome packaging and transport.

Jumbo phages are active against extensively-drug-resistant eyedrop-associated Pseudomonas aeruginosa infections.

The paper identifies jumbo and non-jumbo phages effective against XDR Pseudomonas aeruginosa isolates causing eyedrop-associated infections.

Identifying the core genome of the nucleus-forming bacteriophage family and characterization of Erwinia phage RAY

The paper identifies a core genome of nucleus-forming bacteriophages and characterizes the replication mechanism of Erwinia phage RAY.

Architecture and self-assembly of the jumbo bacteriophage nuclear shell

The paper identifies chimallin as the primary protein forming the bacteriophage nuclear shell and characterizes its self-assembly into closed compartments.

A Cytoskeletal Vortex Drives Phage Nucleus Rotation During Jumbo Phage Replication inE. coli

The paper identifies a cytoskeletal vortex in E. coli jumbo phage Goslar that drives phage nucleus rotation, similar to eukaryotic structures.

Subcellular Organization of Viral Particles During Maturation of Nucleus-Forming Jumbo Phage

The paper visualizes the subcellular organization of mature viral particles in nucleus-forming jumbo phages, revealing a structured assembly process called phage bouquets.

Bacterial Cytological Profiling Identifies Rhodanine-containing PAINS Analogs as Specific Inhibitors of E. coli Thymidylate Kinase in Vivo

Selective transport of fluorescent proteins into the phage nucleus

The paper investigates nuclear transport in phage infection systems, finding that GFPmut1 can be selectively transported into the {Phi}KZ phage nucleus, with specific amino acid residues identified for this process.

Revealing 29 sets of independently modulated genes in Staphylococcus aureus, their regulators and role in key physiological responses

This paper identifies 29 independently modulated gene sets in S. aureus using ICA, linking them to regulators and physiological responses.

Isolation and characterization of Streptomyces bacteriophages and Streptomyces strains encoding biosynthetic arsenals

This study identifies novel Streptomyces strains and phages with potential for antibiotic discovery and genetic manipulation.

Characterizing the response of Acinetobacter baumannii ATCC 17978 to azithromycin in multiple in vitro growth conditions

This study examines how MDR A. baumannii responds to azithromycin in different growth conditions using multiple analytical techniques.

Identifying the effect of vancomycin on HA-MRSA strains using bacteriological and physiological media

The paper examines vancomycin's effect on HA-MRSA USA100 strains using bacteriological and physiological media through growth curves, RNA sequencing, and exo-metabolomics.

Profiling the effect of nafcillin on HA-MRSA D592 using bacteriological and physiological media

This study investigates how nafcillin affects HA-MRSA D592 in different media types, revealing media-dependent antibiotic activity through multi-dimensional analysis.

Phenotypic consequences of RNA polymerase dysregulation in Escherichia coli

This study shows that perturbing RNA polymerase activity in E. coli leads to biphasic growth and increased tolerance to antibacterial stresses.