Primary platinum resistance and immune exclusion in ovarian carcinomas with high expression of the homologous recombination mediator RAD51
M. M. Hoppe, T. Z. Tan, S. Lie, S. Lim, J. P. Yeong, J. D. Wardyn, P. Jaynes, D. G. Lim, B. N. Pang, A. Karnezis, D. Chiu, S. Leung, D. G. Huntsman, A. S. Sedukhina, K. Sato, , A. Jeyasekharan
This study shows that high RAD51 expression in ovarian cancer is linked to poor survival and platinum resistance, particularly in HRD-negative tumors, and correlates with immune exclusion.
bioRxiv · Jun 9, 2020Cancer Biology