Author

D. S. Tan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Benjamin· 1 shared A. Chow· 1 shared A. Jeyasekharan· 1 shared A. Karnezis· 1 shared A. Rizzi· 1 shared A. S. Sedukhina· 1 shared A. Schurer· 1 shared A. Yap· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperMicrobiology

A. Benjamin

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4 papers

Recent·Most cited

Chalkophore mediated respiratory oxidase flexibility controls M. tuberculosis virulence

J. Buglino, Y. Ozakman, C. E. Hatch, A. Benjamin, D. S. Tan, M. Glickman

This study shows that M. tuberculosis uses chalkophores to maintain respiration under copper limitation, which is critical for its virulence in mice.

bioRxiv · Apr 12, 2024Microbiology

Multiscale mechanisms driving tissue rupture by invading cells

S. K. Wu, F. Sun, C. Z. Ho, Y. Lou, C. B.-X. Huang, M. H. Nai, J. Xiao, M. Shagirov, J. F. L. Chin, D. Lim, S. Verma, D. S. Tan, P. Marcq, A. Yap, C. T. Lim, , B. C. Low

This study identifies a mechanism where invading cells and tissue barriers coordinate to rupture barriers through intercellular adhesions and subcellular contractility, challenging existing models of collective invasion.

bioRxiv · Sep 25, 2023Cell Biology

Primary platinum resistance and immune exclusion in ovarian carcinomas with high expression of the homologous recombination mediator RAD51

M. M. Hoppe, T. Z. Tan, S. Lie, S. Lim, J. P. Yeong, J. D. Wardyn, P. Jaynes, D. G. Lim, B. N. Pang, A. Karnezis, D. Chiu, S. Leung, D. G. Huntsman, A. S. Sedukhina, K. Sato, , A. Jeyasekharan

This study shows that high RAD51 expression in ovarian cancer is linked to poor survival and platinum resistance, particularly in HRD-negative tumors, and correlates with immune exclusion.

bioRxiv · Jun 9, 2020Cancer Biology

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

G. Minuesa, S. K. Albanese, A. Chow, A. Schurer, S.-M. Park, C. Z. Rotsides, J. Taggart, A. Rizzi, L. N. Naden, T. Chou, S. Gourkanti, D. Cappel, M. C. Passarelli, L. Fairchild, C. Adura, , M. G. Kharas

This study identifies Ro 08-2750 as a small molecule that targets MSI2 RNA-binding activity, inducing differentiation, apoptosis, and reduced disease burden in AML models.

Nature Communications · Jun 19, 2019Peer-reviewedCancer Biology