The paper shows that cancer cells across different EMT states lack rigidity sensing, often due to missing tumor suppressors like Tpm2.1, and this loss contributes to their transformed phenotype.

bioRxiv · Jun 6, 2022 · PreprintCancer Biology

Case study: Digital spatial profiling of metastatic clear cell carcinoma reveals intra-tumor heterogeneity in epithelial-mesenchymal gradient.

D. Y.-T. Wang, T. Z. Tan, Y.-T. Tai, J. Ye, W.-C. Lin, L.-H. Wei, R. Y.-J. Huang

This study uses spatial profiling to show an epithelial-mesenchymal gradient in metastatic OCCC but not in the primary tumor, revealing intermediate cell states.

bioRxiv · May 27, 2021 · PreprintCancer Biology

TRAF4 inhibits bladder cancer progression by promoting BMP/SMAD signalling pathway

P. V. Iyengar, D. L. Marvin, D. Lama, T. Z. Tan, S. Suriyamurthy, F. Xie, M. van Dinther, H. Mei, C. S. Verma, L. Zhang, L. Ritsma, P. ten Dijke

This study identifies TRAF4 as a tumor suppressor in bladder cancer that promotes BMP/SMAD signaling and inhibits metastasis by targeting SMURF1 for degradation.

bioRxiv · Oct 12, 2020 · PreprintCancer Biology

Primary platinum resistance and immune exclusion in ovarian carcinomas with high expression of the homologous recombination mediator RAD51

M. M. Hoppe, T. Z. Tan, S. Lie, S. Lim, J. P. Yeong, J. D. Wardyn, P. Jaynes, D. G. Lim, B. N. Pang, A. Karnezis, D. Chiu, S. Leung, D. G. Huntsman, A. S. Sedukhina, K. Sato, , A. Jeyasekharan

This study shows that high RAD51 expression in ovarian cancer is linked to poor survival and platinum resistance, particularly in HRD-negative tumors, and correlates with immune exclusion.

bioRxiv · Jun 9, 2020Cancer Biology

Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity

A. Ravasio, M. Z. Myaing, S. Chia, A. Arora, A. Sathe, E. Y. Cao, C. Bertocchi, A. Sharma, B. Arasi, V. Y. Chung, A. C. Green, T. Z. Tan, Z. Chen, H. T. Ong, N. G. Iyer, , V. Viasnoff

The paper develops a single-cell assay to analyze EphA receptor clustering in cancer cells, revealing its persistence through division and association with migration and drug resistance.

bioRxiv · May 10, 2019Cancer Biology

DNA methylation profiling of breast cancer cell lines along the epithelial mesenchymal spectrum - implications for the choice of circulating tumour DNA methylation markers

A. Viet-Phuong Le, M. Szaumkessel, T. Z. Tan, J.-P. Thiery, E. W. Thompson, A. Dobrovic

The paper examines DNA methylation differences between epithelial and mesenchymal breast cancer cell lines to identify suitable biomarkers for circulating tumour DNA methylation.

bioRxiv · Aug 31, 2017Cancer Biology