Potentiation of drug toxicity through virus latency reversal promotes preferential elimination of HIV infected cells
T. Truong, M. Hayn, C. Kaas Frich, L. K. Ladefoged, M. Jarlstad Olesen, J. Jakobsen, C. Lunaberg, B. Schiott, J. Muench, A. N. Zelikin
The paper demonstrates that latency reversal enhances the toxicity of HIV protease-activated toxins, preferentially eliminating HIV-infected cells in mixed populations.
bioRxiv · Jan 12, 2022Pharmacology & Toxicology