Author

L. K. Ladefoged

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:mechanistic / dynamical model· 2 Research Focus:protein folding & dynamics· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. Schiott· 3 shared A. J. Pedersen· 1 shared A. N. Zelikin· 1 shared A. S. Kristensen· 1 shared B. Bang-Andersen· 1 shared B. Schioett· 1 shared C. C. Brun· 1 shared C. Chipot· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

B. Schiott

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural Determinants for Activity of the Antidepressant Vortioxetine at Human and Rodent 5-HT3 receptors

U. Lopez-Sanchez, L. J. Munro, L. K. Ladefoged, A. J. Pedersen, C. C. Brun, S. M. Lyngby, D. Baud, M. G. Pedersen, S. C. R. Lummis, B. Bang-Andersen, B. Schiott, C. Chipot, G. Schoehn, J. Neyton, F. Dehez, , A. S. Kristensen

This study investigates how vortioxetine interacts with human and rodent 5-HT3 receptors, revealing structural differences and mechanisms of action.

bioRxiv · Feb 23, 2024 · PreprintBiochemistry

Potentiation of drug toxicity through virus latency reversal promotes preferential elimination of HIV infected cells

T. Truong, M. Hayn, C. Kaas Frich, L. K. Ladefoged, M. Jarlstad Olesen, J. Jakobsen, C. Lunaberg, B. Schiott, J. Muench, A. N. Zelikin

The paper demonstrates that latency reversal enhances the toxicity of HIV protease-activated toxins, preferentially eliminating HIV-infected cells in mixed populations.

bioRxiv · Jan 12, 2022Pharmacology & Toxicology

Binding and activation of serotonergic G-protein coupled receptors by the multimodal antidepressant vortioxetine.

L. K. Ladefoged, R. Koch, P. C. Biggin, B. Schioett

This study uses in silico analysis to examine vortioxetine's binding and activation mechanisms at 5-HT1A, 5-HT1B, and 5-HT7 receptors, revealing insights into agonist-antagonist behavior and activation without hydrogen bonding to helix 5.

bioRxiv · Jan 5, 2021Biophysics

Beneficent and maleficent effects of cations on bufadienolide binding to Na+,K+-ATPase

L. K. Ladefoged, B. Schiott, N. U. Fedosova

The paper investigates how different cations affect bufadienolide binding to Na+,K+-ATPase using docking and molecular dynamics simulations, revealing electrostatic and structural effects of cations on the binding site.

bioRxiv · Nov 9, 2020Biophysics