J. K. Freundt

Titin-based force regulates cardiac myofilament structures mediating length-dependent activation

The paper investigates how titin-based forces affect cardiac myofilament structures under stretch, supporting the Frank-Starling mechanism.

Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle

This study uses a titin-cleavage mouse model to show that titin cleavage reduces passive and active forces and disrupts A-band stability during muscle contraction.