A. L. Hessel

Remodelling of Skeletal Muscle Myosin Metabolic States in Hibernating Mammals

This study examines changes in skeletal muscle myosin metabolic states during hibernation in different mammals, finding reduced ATP consumption and potential mechanisms for energy conservation.

Titin-based force regulates cardiac myofilament structures mediating length-dependent activation

The paper investigates how titin-based forces affect cardiac myofilament structures under stretch, supporting the Frank-Starling mechanism.

Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure.

This study investigates the effects of MyBP-C knockout in skeletal muscle, finding altered length-dependent activation and myofilament structure, with implications for MyBP-C-related diseases.

Myosin-binding protein C forms C-links and stabilizes OFF states of myosin

This study shows that MyBP-CC1C7 domains form C-links and stabilize myosin OFF states, affecting crossbridge kinetics and sarcomere function.

The distinctive mechanical and structural signatures of residual force enhancement in myofibers

The paper investigates titin's role in residual force enhancement (RFE) in muscle by analyzing structural changes in myofibers with and without titin cleavage and in a mutant strain.

Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle

This study uses a titin-cleavage mouse model to show that titin cleavage reduces passive and active forces and disrupts A-band stability during muscle contraction.

Triceps surae torque-length relationships relevant for walking activity levels with and without an ankle exoskeleton

This study examines how ankle exoskeletons affect torque-length properties of plantar flexor muscles during walking, finding that reduced muscle activity shifts these properties to longer fascicle lengths and dorsiflexed angles.