W. A. Linke

Titin-based force regulates cardiac myofilament structures mediating length-dependent activation

The paper investigates how titin-based forces affect cardiac myofilament structures under stretch, supporting the Frank-Starling mechanism.

Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure.

This study investigates the effects of MyBP-C knockout in skeletal muscle, finding altered length-dependent activation and myofilament structure, with implications for MyBP-C-related diseases.

Myosin-binding protein C forms C-links and stabilizes OFF states of myosin

This study shows that MyBP-CC1C7 domains form C-links and stabilize myosin OFF states, affecting crossbridge kinetics and sarcomere function.

Imaging of existing and newly translated proteins elucidates mechanisms of sarcomere turnover

The paper uses imaging to show that sarcomere proteins are replaced by newly translated ones, disproving the existing protein pool model and revealing a unidirectional replacement mechanism.

The distinctive mechanical and structural signatures of residual force enhancement in myofibers

The paper investigates titin's role in residual force enhancement (RFE) in muscle by analyzing structural changes in myofibers with and without titin cleavage and in a mutant strain.

Correcting dilated cardiomyopathy with fibroblast-targeted p38 deficiency

This study shows that targeting p38 in cardiac fibroblasts can reverse fibrosis and improve cardiomyocyte function in a mouse model of dilated cardiomyopathy.

Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle

This study uses a titin-cleavage mouse model to show that titin cleavage reduces passive and active forces and disrupts A-band stability during muscle contraction.

A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues

The paper introduces a HaloTag-TEV genetic cassette to study protein mechanics in native tissues, showing titin's role in muscle contraction under mechanical forces.