Gli1+ mesenchymal stromal cells modulate epithelial metaplasia in lung fibrosis
M. Cassandras, C. Wang, J. Kathiriya, T. Tsukui, P. Matatia, M. Matthay, P. Wolters, A. Molofsky, D. Sheppard, H. Chapman, T. Peng
This study shows Gli1+ mesenchymal stromal cells drive metaplastic differentiation of airway progenitors into KRT5+ basal cells in fibrosis by modulating BMP activation through hedgehog signaling.
bioRxiv · Nov 14, 2019Cell Biology