Author

H. Chapman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Barty· 1 shared A. D. Borowsky· 1 shared A. M. Katz· 1 shared A. Mancuso· 1 shared A. Molofsky· 1 shared A. OurmazdiD· 1 shared A. Sadri· 1 shared A. Tolstikova· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperBiophysics

A. Barty

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Author profile →

4 papers

Recent·Most cited

Nonlinear progression during the occult transition establishes cancer lethality

J. D. Ginzel, H. Chapman, J. E. Sills, E. J. Allen, L. S. Barak, R. D. Cardiff, A. D. Borowsky, H. K. Lyerly, B. W. Rogers, J. C. Snyder

This study shows that cancer progression is nonlinear, with a critical occult transition leading to lethal tumors before detection, challenging the linear model of cancer growth.

bioRxiv · Apr 23, 2024Cancer Biology

Direct Observation of the Mechanism of Antibiotic Resistance by Mix-and-Inject at the European XFEL

S. Pandey, G. Calvey, A. M. Katz, T. N. Malla, F. Koua, J. Martin-Garcia, I. Poudyal, J.-H. Yang, M. Vakili, O. Yefanov, K. A. Zielinski, S. Bajt, S. Awel, K. Doerner, M. Frank, , M. Schmidt

The paper directly observes fast ligand binding in a biomedically relevant enzyme using MHz X-ray pulses at the European XFEL.

bioRxiv · Nov 24, 2020 · PreprintBiophysics

Gli1+ mesenchymal stromal cells modulate epithelial metaplasia in lung fibrosis

M. Cassandras, C. Wang, J. Kathiriya, T. Tsukui, P. Matatia, M. Matthay, P. Wolters, A. Molofsky, D. Sheppard, H. Chapman, T. Peng

This study shows Gli1+ mesenchymal stromal cells drive metaplastic differentiation of airway progenitors into KRT5+ basal cells in fibrosis by modulating BMP activation through hedgehog signaling.

bioRxiv · Nov 14, 2019Cell Biology

HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression

J. Schloss, R. Ali, J. J. Racine, H. Chapman, D. Serreze, T. DiLorenzo

This paper develops a mouse model expressing HLA-B*39:06 without murine class I MHC and shows it leads to T1D with reduced thymic insulin expression, despite normal T cell development.

bioRxiv · Feb 13, 2018Immunology