The mitochondrial deubiquitinase USP30 regulates AKT/mTOR signaling
R. Zhang, J. Krigman, S. Ozgen, H. Luo, Y. Zhao, G. Xin, N. Sun
This study shows Parkin promotes AKT degradation during mitophagy, while USP30 protects AKT, influencing cell apoptosis and USP30's broader physiological roles.
bioRxiv · Oct 25, 2021Pharmacology & Toxicology