J. L. J. Coleman

Orphan G protein-coupled receptor, GPR37L1: pharmacological toolbox empty once again

The paper corrects a cloning error in a 2017 study on GPR37L1 ligand discovery and reports unsuccessful re-testing of predicted ligands, leading to a retraction initiative.

The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases

This study identifies matrix metalloprotease-mediated cleavage of GPR37L1's N-terminus as a regulatory mechanism that inactivates the receptor.