Author

R. M. Graham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

N. J. Smith· 2 shared S. E. Iismaa· 2 shared S. Kesteven· 2 shared A. Chan· 1 shared A. Husain· 1 shared A. J. Cleave· 1 shared A. J. Waardenberg· 1 shared A. M. Nicks· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

N. J. Smith

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Standardised method for cardiomyocyte isolation and purification from individual murine neonatal, infant, and adult hearts

A. M. Nicks, S. R. Holman, A. Y. Chan, M. Tsang, P. E. Young, D. T. Humphreys, N. Naqvi, A. Husain, M. Li, N. J. Smith, S. E. Iismaa, R. M. Graham

This paper develops a standardized method to isolate and purify high-quality cardiomyocytes from murine hearts of all postnatal ages, revealing sex-specific genes and preserving cell morphology.

bioRxiv · Sep 30, 2021Cell Biology

The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy

Y. Guo, J. Yu, Y. Wu, H. Gong, S. Kesteven, S. E. Iismaa, A. Chan, S. Holman, S. Pinto, A. Pironet, C. Cox, R. Vennekens, R. M. Graham, M. P. Feneley, B. Martinac

This study identifies TRPM4 as a key regulator of pressure overload-induced cardiac hypertrophy by modulating CaMKII{delta}-HDAC4-MEF2A and calcineurin-NFAT-GATA4 pathways in mice.

bioRxiv · Dec 21, 2020Physiology

The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases

J. L. J. Coleman, T. Ngo, R. E. Smythe, A. J. Cleave, N. M. Jones, R. M. Graham, N. J. Smith

This study identifies matrix metalloprotease-mediated cleavage of GPR37L1's N-terminus as a regulatory mechanism that inactivates the receptor.

bioRxiv · Jun 27, 2020Biochemistry

PDGFR alpha signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair

N. S. Asli, M. Xaymardan, R. Patrick, N. Farbehi, J. Cornwell, E. Forte, A. J. Waardenberg, V. Janbandhu, S. Kesteven, V. Chandrakanthan, H. Malinowska, H. Reinhard, P. Schofield, D. Christ, I. Ahmed, , R. P. Harvey

This study investigates how PDGFR alpha signaling in cardiac fibroblasts affects quiescence, metabolism, and self-renewal, leading to improved heart repair after myocardial infarction.

bioRxiv · Jun 13, 2019 · PreprintCell Biology