R. E. Smythe

Development of supramolecular anticoagulants with on-demand reversibility

This paper develops supramolecular anticoagulants that can be reversed on demand using a PNA antidote, demonstrating potent in vitro and in vivo anticoagulant activity.

The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases

This study identifies matrix metalloprotease-mediated cleavage of GPR37L1's N-terminus as a regulatory mechanism that inactivates the receptor.